Writers and Readers of DNA Methylation/Hydroxymethylation in Physiological Aging and Its Impact on Cognitive Function

Figure 1

Aging-induced changes in the expression of epigenetic mediators. (a) Aging is associated with decreased DNMT1, DNMT3a1, DNMT3a2, TET1, and TET2 expression. Conversely, Mecp2 expression is increased in postmortem human samples. (b) The exposure to environmental stimulation could diminish or revert the aging-associated alterations in the expression of epigenetic mediators, as it has been observed for TET2 and physical exercise and DNMT1 activity in glucose restriction.

(a)

(b)