(a)
(b)
(c)
(d)
Figure 1: Widespread distribution of GDNF in the rat striatum. Photomicrographs of widespread GDNF immunoreactivity in the striatum of rats implanted with the lower dose GDNF-secreting device (a) and associated immunoreactivity in the substantia nigra (c). Histograms of the mean (±SEM) of the volume (b) and optical density (d) of GDNF staining. .