Widespread Striatal Delivery of GDNF from Encapsulated Cells Prevents the Anatomical and Functional Consequences of Excitotoxicity

Figure 2

Protection of striatal neurons against QA toxicity. Photomicrographs of NeuN immunoreactivity illustrating an extensive loss of striatal neurons (a) that is largely prevented by prior implantation with the lower dose GDNF-secreting device (c). Quantification of striatal neurons (b) confirmed the extensive neuroprotection induced by GDNF with greater benefits observed in those animals receiving the higher dose implants. Quantification of the striatal volume further illustrated both the extensive nature of the QA lesion and the robust neuroprotection in GDNF-treated animals (d). ; .

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