Brain Hemodynamic Intermediate Phenotype Links Vitamin B₁₂ to Cognitive Profile of Healthy and Mild Cognitive Impaired Subjects

Figure 2

Neuropsychological assessment results. (a) Correlations among all the seventeen neuropsychological tests as estimated by Pearson’s coefficient. Marked cells refer to significant correlations corrected for multiple comparisons through the False Discovery Rate procedure. (b) Matrix describing the results of the principal component analysis and showing seventeen uncorrelated cognitive profiles, tests loadings, and the proportion of variance explained by each component. As a matter of fact, the first principal component (explained variance: 29.1%) highlighted subjects’ global cognitive performance, since all the neuropsychological tests jointly contributed to it and given its high correlation with MMSE scores (, ). AVLT: Auditory Verbal Learning Test; Imm: immediate recall; Delay: delayed recall.

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