Brain Hemodynamic Intermediate Phenotype Links Vitamin B₁₂ to Cognitive Profile of Healthy and Mild Cognitive Impaired Subjects

Figure 3

Brain activity results. (a) fMRI task-evoked activity across subjects entails medial and lateral occipital regions (i.e., primary and motion-sensitive visual cortex), the dorsal parietal attention network (intraparietal sulcus and superior parietal lobule), frontal areas involved in motor control and focusing (ventral and dorsal premotor, as well as the supplementary motor), and nodes of the salience network (e.g., anterior insula). Regions enclosed in black survived the Bonferroni correction for multiple comparisons (). (b) Results for the relationship between biochemical markers and task-evoked brain activity. Hemodynamic activity of the right dorsal anterior cingulate cortex (dACC), located within the task-positive network, was found to be significantly associated with B₁₂ serum concentrations (two-tailed for the cluster-forming threshold and for cluster significance).

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