Ganglionic Long-Term Potentiation in Prehypertensive and Hypertensive Stages of Spontaneously Hypertensive Rats Depends on GABA Modulation

Figure 2

SCG of SHR expressed LTP at 6 wo but not at 12 wo. (a) Time course of synaptic potentiation expressed as () and recorded in ganglia isolated from young (6 wo) SHR (black circles) and adult (12 wo) hypertensive SHR (white circles). Bar plots of LTP parameters analyzed showing that LTP was expressed in 6 wo SHR, whereas it was not present in 12 wo SHR animals (LTP decay of and LTP extent of for 6 wo SHR () and LTP decay of and LTP extent of for 12 wo SHR (); and , respectively). (c) Time course of synaptic potentiation, (), recorded in ganglia isolated from 6 wo (black triangles) and 12 wo WKy rats (white triangles). (d) LTP was not expressed in SCG of 6 wo WKy rats, but was expressed in 12 wo WKy rats (LTP decay of and LTP extent of for 6 wo WKy rats () and LTP decay of and LTP extent of for 12 wo WKy rats (); and , respectively). Dotted lines in (a) and (c) indicate the LTP baseline value (0.2).

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