Neural Plasticity / 2019 / Article / Tab 2

Research Article

iTRAQ-Based Protein Profiling in CUMS Rats Provides Insights into Hippocampal Ribosome Lesion and Ras Protein Changes Underlying Synaptic Plasticity in Depression

Table 2

MCL clusters of upregulated proteins.

ClusterGene/displayed nameBiological processMolecular functionCellular component

1Syne1Golgi organization, brain development, response to light stimulus, establishment of nucleus localization, muscle cell differentiation, positive regulation of receptor-mediated endocytosis, regulation of dendrite morphogenesis, cytoskeletal anchoring at nuclear membrane, nuclear matrix anchoring at nuclear membraneActin binding, receptor binding, structural molecule activity, protein binding, lamin binding, enzyme binding, identical protein binding, protein homodimerization activity, poly(A) RNA binding, actin filament bindingNucleus, nuclear envelope, nucleoplasm, cytoplasm, Golgi apparatus, spindle, integral component of membrane, sarcomere, midbody, nuclear membrane, LINC complex, dendritic spine, postsynaptic membrane, perinuclear region of cytoplasm
Rap2bMicrovillus assembly, platelet activation, negative regulation of cell migration, positive regulation of protein autophosphorylation, Rap protein signal transduction, regulation of protein tyrosine kinase activity, platelet aggregation, establishment of endothelial intestinal barrierGTP binding, GDP binding, protein domain-specific bindingCytosol, plasma membrane, bicellular tight junction, membrane, cell-cell contact zone, membrane raft, recycling endosome, recycling endosome membrane, extracellular exosome
Rap2aPositive regulation of protein phosphorylation, small GTPase-mediated signal transduction, microvillus assembly, negative regulation of cell migration, actin cytoskeleton reorganization, positive regulation of protein autophosphorylation, Rap protein signal transduction, cellular protein localization, cellular response to drug, establishment of protein localization, establishment of epithelial cell apical/basal polarity, regulation of JNK cascade, regulation of dendrite morphogenesis, protein localization to plasma membraneGTPase activity, GTP bindingIntracellular, cytosol, plasma membrane, membrane, recycling endosome, recycling endosome membrane, extracellular exosome
ChpMicrotubule bundle formation, negative regulation of protein phosphorylation, negative regulation of protein kinase activity, protein export from nucleus, negative regulation of phosphatase activity, calcium ion-regulated exocytosis, calcium-mediated signaling, membrane docking, cytoplasmic microtubule organization, negative regulation of protein ubiquitination, negative regulation of protein autophosphorylation, negative regulation of NF-kappaB transcription factor activity, positive regulation of sodium : proton antiporter activity, negative regulation of protein import into nucleus, transcytosis, protein stabilization, positive regulation of protein transport, protein oligomerization, regulation of intracellular pH, positive regulation of protein glycosylation, membrane organization, membrane fusion, negative regulation of calcineurin-NFAT signaling cascade, cellular response to acidic pH, positive regulation of protein targeting to membrane, regulation of neuron deathProtein kinase inhibitor activity, transporter activity, calcium ion binding, protein binding, microtubule binding, kinase binding, calcium-dependent protein bindingGolgi membrane, nucleus, cytoplasm, endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, cytosol, plasma membrane, focal adhesion, microtubule cytoskeleton, transport vesicle, extracellular exosome
Ap1s2Intracellular protein transport, visual learning, vesicle-mediated transport, synaptic vesicle recycling, fat cell differentiation, neuromuscular process controlling balance, adipose tissue developmentProtein transporter activityGolgi apparatus, membrane coat, intracellular membrane-bounded organelle

2Dynll1Transcription, DNA-templated, regulation of transcription, DNA-templated, nitric oxide biosynthetic process, transport, apoptotic process, microtubule-based process, substantia nigra development, intraciliary retrograde transport, neurotransmitter metabolic process, negative regulation of phosphorylation, negative regulation of catalytic activity, motile cilium assembly, cilium morphogenesis, positive regulation of nonmotile primary cilium assemblyMotor activity, enzyme inhibitor activity, protein binding, protein C-terminus binding, enzyme binding, protein domain-specific binding, nitric oxide synthase regulator activity, protein homodimerization activity, dynein intermediate chain bindingKinetochore, nucleus, cytoplasm, mitochondrion, centrosome, cytosol, cytoskeleton, cytoplasmic dynein complex, microtubule, cilium, COP9 signalosome, membrane, extracellular exosome, mitotic spindle
Arcn1Retrograde vesicle-mediated transport, Golgi to ER, adult locomotor behavior, protein transport, cerebellar Purkinje cell layer maturation, pigmentation, Golgi vesicle transportPoly(A) RNA bindingGolgi membrane, cytoplasm, endoplasmic reticulum, Golgi apparatus, membrane, COPI vesicle coat, COPI-coated vesicle, intracellular membrane-bounded organelle
ThResponse to hypoxia, synaptic transmission, dopaminergic, response to amphetamine, dopamine biosynthetic process from tyrosine, fatty acid metabolic process, sphingolipid metabolic process, heart development, visual perception, sensory perception of sound, learning, memory, mating behavior, locomotor behavior, regulation of heart contraction, response to water deprivation, response to light stimulus, response to herbicide, response to salt stress, organ morphogenesis, response to metal ion, response to zinc ion, multicellular organism aging, response to organic cyclic compound, response to activity, aminergic neurotransmitter loading into synaptic vesicle, glycoside metabolic process, response to insecticide, phthalate metabolic process, cerebral cortex development, response to nutrient levels, response to estradiol, response to lipopolysaccharide, isoquinoline alkaloid metabolic process, response to nicotine, social behavior, cellular response to drug, response to isolation stress, response to immobilization stress, neurotransmitter biosynthetic process, terpene metabolic process, dopamine biosynthetic process, epinephrine biosynthetic process, norepinephrine biosynthetic process, catecholamine biosynthetic process, eye photoreceptor cell development, response to drug, circadian sleep/wake cycle, eating behavior, response to peptide hormone, response to ethanol, response to ether, response to pyrethroid, response to steroid hormone, embryonic camera-type eye morphogenesis, cognition, protein homotetramerization, response to corticosterone, response to electrical stimulus, phytoalexin metabolic process, oxidation-reduction process, response to growth factor, cellular response to manganese ion, cellular response to alkaloid, cellular response to nicotine, cellular response to glucose stimulus, cellular response to growth factor stimulusMonooxygenase activity, tyrosine 3-monooxygenase activity, protein binding, ferrous iron binding, ferric iron binding, amino acid binding, oxygen binding, enzyme binding, protein domain-specific binding, tetrahydrobiopterin binding, dopamine bindingNucleus, cytoplasm, mitochondrion, smooth endoplasmic reticulum, cytosol, synaptic vesicle, cytoplasmic side of plasma membrane, axon, dendrite, cytoplasmic vesicle membrane, cytoplasmic vesicle, melanosome membrane, neuron projection, neuronal cell body, terminal bouton, perikaryon
Stx5Intracellular protein transport, ER to Golgi vesicle-mediated transport, early endosome to Golgi transport, retrograde transport, endosome to Golgi, positive regulation of protein catabolic process, vesicle docking, vesicle fusion with Golgi apparatus, Golgi disassembly, cell-cell adhesion, regulation of Golgi organizationSNARE binding, SNAP receptor activity, protein binding, protein N-terminus binding, cadherin binding involved in cell-cell adhesionGolgi membrane, nucleoplasm, endoplasmic reticulum, Golgi apparatus, cytosol, cell-cell adherens junction, integral component of membrane, SNARE complex, vesicle, endoplasmic reticulum-Golgi intermediate compartment membrane

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