Neural Plasticity / 2019 / Article / Tab 3

Research Article

iTRAQ-Based Protein Profiling in CUMS Rats Provides Insights into Hippocampal Ribosome Lesion and Ras Protein Changes Underlying Synaptic Plasticity in Depression

Table 3

MCL clusters of downregulated proteins.

ClusterGene/displayed nameBiological processMolecular functionCellular component

3Mrps5TranslationStructural constituent of ribosome, poly(A) RNA bindingMitochondrion, mitochondrial small ribosomal subunit, cytosolic small ribosomal subunit
Psmb4Negative regulation of inflammatory response to antigenic stimulus, proteolysis involved in cellular protein catabolic processLipopolysaccharide binding, threonine-type endopeptidase activityProteasome complex, nucleus, cytoplasm, proteasome core complex, extracellular exosome
Mrpl46/Structural constituent of ribosome, hydrolase activityNucleoplasm, mitochondrion, mitochondrial large ribosomal subunit, cell junction
RGD1561333Cytoplasmic translationRNA binding, structural constituent of ribosome, poly(A) RNA bindingNucleolus, focal adhesion, membrane, cytosolic large ribosomal subunit
Anp32bVasculature development, nucleosome assembly, nucleocytoplasmic transport, activation of cysteine-type endopeptidase activity involved in apoptotic process, positive regulation of cell proliferation, ventricular system development, negative regulation of apoptotic process, regulation of cysteine-type endopeptidase activity involved in apoptotic process, histone exchange, negative regulation of cell differentiation, positive regulation of protein export from nucleus, inner ear development, palate development, positive regulation of G1/S transition of mitotic cell cycleProtein binding, histone binding, RNA polymerase bindingNucleus, nucleolus, cytoplasm, extracellular exosome
Fam136a//Cytoplasm, mitochondrion
Rpl14rRNA processing, translation, ribosomal large subunit biogenesisStructural constituent of ribosome, poly(A) RNA bindingCytoplasm, ribosome, membrane, cytosolic large ribosomal subunit, extracellular exosome

4Tbc1d13Intracellular protein transport, regulation of vesicle fusion, activation of GTPase activity, regulation of cilium assemblyGTPase activator activity, Rab GTPase bindingIntracellular, endomembrane system
Neo1Neuron migration, regulation of transcription, DNA templated, cell adhesion, axon guidance, myoblast fusion, positive regulation of BMP signaling pathway, regulation of axon regeneration, negative regulation of axon regeneration, negative regulation of protein secretion, iron ion homeostasis, negative regulation of neuron death, regulation of neuron migrationReceptor activity, signaling receptor activity, coreceptor binding, cadherin binding, BMP receptor bindingNucleoplasm, Golgi apparatus, plasma membrane, integral component of plasma membrane, cell surface, membrane, neuronal cell body, intracellular vesicle, plasma membrane protein complex
Arhgap12Morphogenesis of an epithelial sheet, signal transduction//
Dnajc27Small GTPase-mediated signal transduction, positive regulation of MAPK cascade, positive regulation of ERK1 and ERK2 cascades, regulation of MAPK export from nucleusGTPase activity, GTP bindingNucleus, mitochondrion

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