Systematic Analysis of Environmental Chemicals That Dysregulate Critical Period Plasticity-Related Gene Expression Reveals Common Pathways That Mimic Immune Response to Pathogen

<div>Environmental chemicals preferentially impact expression of genes downregulated in the critical period brain plasticity signatures of juvenile and Lynx1-/- mice. (a) We generated two in vivo critical period transcriptome signatures (juvenile at the peak of the endogenous critical period at P26 and Lynx1-/- adult mice, which maintain critical period-like plasticity) from public data. (b) Environmental chemical signatures using genes either increased or decreased by a given chemical (CHEM composite) were derived from the Comparative Toxicogenomics Database. (c) Molecular matches were computed to the critical period signatures using Gene Set Enrichment Analysis (GSEA) to identify that chemicals preferentially impact genes downregulated in the critical period signatures.</div>

Neural Plasticity

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Figure 1: Systematic Analysis of Environmental Chemicals That Dysregulate Critical Period Plasticity-Related Gene Expression Reveals Common Pathways That Mimic Immune Response to Pathogen 

Figure 1 | Systematic Analysis of Environmental Chemicals That Dysregulate Critical Period Plasticity-Related Gene Expression Reveals Common Pathways That Mimic Immune Response to Pathogen 