Brain-Derived Neurotrophic Factor and Its Potential Therapeutic Role in Stroke Comorbidities

Figure 2

Schematic of neurotrophins and their target receptors. NGF, BDNF/NT-4, and NT-3 bind to TrkA, TrkB, and TrkC, respectively, with high affinity. While these neurotrophins can all also bind to p75^NTR with low affinity, the proneurotrophins proNGF and proBDNF can bind and activate the p75^NTR receptor with high affinity. Trk: tropomyosin receptor kinase; NGF: nerve growth factor; BDNF: brain-derived neurotrophic factor; NT: neurotrophin; Ig: immunoglobulin; TMD: transmembrane domain; ECS: extracellular space; ICS: intracellular space. This cartoon is adopted from Sanchez-Sanchez et al. with modifications [24].