Outcomes and Adverse Effects of Deep Brain Stimulation on the Ventral Intermediate Nucleus in Patients with Essential Tremor
Table 1
Details of studies included in a meta-analysis of DBS in treatment of ET.
Authors & year
No. of Pts
Age in Yrs (range)
Duration of ET in Yrs (range)
Site of lesion
Follow-up in Mons
Unil/Bil
Voltage (V)
Pulse widths (μs)
Preoperative tremor scores
Postoperative tremor scores
Type of TRS
Percentage change in any TRS (%)
Koller W.C et al. 2001
25
VIM
Unil
FTM-TRS
78.5
Ondo et al. 2001
13
NS
VIM
3
Bil
NS
NS
MTRS
80.6
Pahwa R et al. 2001
17
73.1 (62–82)
NS
VIM
3.1
Unil
NS
NS
FTM-TRS
50.5
Fields J.A et al. 2003
40
VIM
12
Unil
L: R:
L: R:
FTM-TRS
56.3
Papavassiliou E et al. 2004
37
NS
VIM
21 Unil/16 Bil
FTM-TRS
52.8
Kuncel A.M et al. 2006
14
NS
VIM
NS
FTM-TRS
98.3
Van den Wildenberg WP et al. 2006
10
VIM
NS
NS
NS
NS
FTM-TRS
36.6
Pahwa R et al. 2006
22
NS
VIM
60
3 Unil/20 Bil
3.6
111
FTM-TRS
58.2
Blomstedt et al. 2007
19
NS
VIM
13
Unil
ETRS
49.3
Ellis TM et al. 2008
5
VIM
NS
NS
NS
FTM-TRS
60.4
Zhang K et al. 2010
34
VIM
56.9
23 Unil/11 Bil
FTM-TRS
80.4
Morishita. et al. 2010
19
VIM
6
Unil
NS
ND
MTRS
74.8
Graft-Radford et al. 2010
31
VIM
6
22 Unil/9 Bil
Unil: 2.7 Bil (L): 2.7 Bil (R): 2.9
Unil: 102 Bil (L): 7 8 Bil (R): 9 3
FTM-TRS
60.5
Barbe et al. 2011
21
VIM
2.5
3 Unil/ 20 Bil
NS
NS
FTM-TRS
32.4
Vassal F et al. 2012
7
NS
NS
VIM
NS
NS
NS
FTM-TRS
90.3
Zahos P.A. et al. 2013
7
VIM
3 Unil/4 Bil
NS
NS
ETRS
75.8
Felicitas Ehlen et al. 2014
13
VIM
Unil
UPDRSa
68.5
Rodríguez, C et al. 2016
14
VIM
6
3 Unil/11 Bil
FTM-TRS
73.5
Isaacs D.A et al. 2018
7
NS
VIM
NS
NS
NS
NS
FTM-TRS
60.8
Paschen et al. 2018
21
NS
NS
VIM
NS
Bil
NS
NS
TRSb
62.0
Barbe M.T et al. 2018
13
VIM, PSA
12
NS
NS
NS
FTM-TRS
49.8
Akram H et al. 2018
5
VIM
Unil
FTM-TRS
41.2
Fenoy, A.J et al. 2018
20
62.8 (18-81)
VIM
12
2 Unil/18 Bil
ETRS
81.0
Paschen et al. 2019
20
VIM
Bil
L: R:
L: R:
ETRS
62.9
Morishit T et al. 2019
3
VIM
Unil
ETRS
44.0
Reich M et al. 2017
2
73
NS
VIM
NS
Bil
NS
NS
FTM-TRS
52.9
Pooled
439
—
—
—
—
—
—
—
—
—
—
61.3,
NS: not specified; Pts: patients; ET: essential tremor; Unil: Unilateral; Bil: Bilateral; TRS: Tremor Rating Scale; ETRS: Essential Tremor Rating Scale; Mons: Months. FTM: the Fahn-Tolosa-Marin; MTRS: Modified Tremor Rating Scale; UPDRS: the Unified Parkinson Disease Rating Scale. Unless otherwise stated, values are presented as the .aTremor intensity was defined using the sum score of UPDRS subitems 20 and 21 (tremor at rest, action, and postural). bThe detailed type of TRS was not definite in Paschen et al. 2018.
