High Frequency of AIFM1 Variants and Phenotype Progression of Auditory Neuropathy in a Chinese Population

Figure 5

(a, b) The change of pure tone threshold of 0.5 kHz over time in both ears of AIFM1-positive AN patients. Spline smoothing was performed using GAMM (generalized additive mixed model) to explore the change of pure tone threshold with the length of follow-up time. The solid lines represent the fitting spline. The dashed lines represent the 95% confidence intervals. The vertical axis measures the change in pure tone hearing. The rug plot provides a visual representation of the frequency distribution for follow-up time. Each individual data point is represented by a single tick mark at the appropriate location on the chosen time scale (days).