High Frequency of AIFM1 Variants and Phenotype Progression of Auditory Neuropathy in a Chinese Population

Figure 6

The change of pure tone threshold of 0.25, 1, 2, 4, and 8 kHz over time in both ears of AIFM1-positive AN patients. Spline smoothing was performed using GAMM (generalized additive mixed model) to explore the change of pure tone threshold with the length of follow-up time. The solid lines represent the fitting spline. The dashed lines represent the 95% confidence intervals.