Exercise-Induced Adaptations to the Mouse Striatal Adenosine System

Figure 1

Striatal A₁R and A_2AR protein expression following three or eight weeks of wheel running. Representative immunohistochemistry images for A₁R in the mouse striatum following eight weeks of (a) sedentary conditions and (b) running wheel access. (c) Relative levels of A₁R protein density represented as averages across sections as detailed in the Methods. Representative immunohistochemistry images for A_2AR in the mouse striatum following eight weeks of (d) sedentary conditions and (e) running wheel access. (f) Relative levels of A_2AR protein density represented as averages across sections as detailed in Methods. Statistical significance denoted as follows: sedentary 8 weeks vs. runner 8 weeks at ^A, ^B, and ^C. Sedentary 8 weeks vs. runner 3 weeks at ^D, ^E, and ^F. Sedentary 8 weeks vs. sedentary 3 weeks at ^G, ^H, and ^I. Runner 8 weeks vs. sedentary 3 weeks at ^J. Runner 8 weeks vs. runner 3 weeks at ^K and ^L. Sedentary 3 weeks vs. runner 3 weeks at ^M.

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