In Vivo Plasticity at Hippocampal Schaffer Collateral-CA1 Synapses: Replicability of the LTP Response and Pharmacology in the Long-Evans Rat

<div>Schematic presentation of electrical stimulation protocols that induce LTP at the SC-CA1 synapses in anesthetized rats. A high-frequency stimulation protocol consists of 10 trains, 1 train consisting of 20 pulses at 200 Hz with (a) a 2 s interval between each train, (b) TBS (2 or 5 trains with 5 bursts per train of 4 pulses at 100 Hz, 200 <i>μ</i>s), and (c) paired pulses (200 ms, 0.05 Hz) delivered at different lengths of interstimulus intervals of 50 ms and 30 ms before and after the standard 200 Hz HFS protocol.</div>

Neural Plasticity

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Figure 1: In Vivo Plasticity at Hippocampal Schaffer Collateral-CA1 Synapses: Replicability of the LTP Response and Pharmacology in the Long-Evans Rat 

Figure 1 | In Vivo Plasticity at Hippocampal Schaffer Collateral-CA1 Synapses: Replicability of the LTP Response and Pharmacology in the Long-Evans Rat 