In Vivo Plasticity at Hippocampal Schaffer Collateral-CA1 Synapses: Replicability of the LTP Response and Pharmacology in the Long-Evans Rat

Figure 10

Scopolamine (0.64 mg/kg) had no significant effect on the LTP response in LE rats. (a) Collective input/output curves between stimulation voltage and fEPSP slope overlap and show no significant difference in basal synaptic excitability. (b) Both scopolamine (red, ) and control, vehicle-treated (black, ) subjects had an increase in fEPSP in response to tetanisation; however, there was no significant difference in the LTP response throughout the 2-hour posttetanisation. Values represent . Outsets above LTP curves represent average waveform field potentials during 30 min baseline prior to tetanisation and 0-30 min and 90-120 min posttetanisation. Horizontal bar: 1 mV; vertical bar: 5 ms. (c) PTP, STP, and LTP responses are presented as .

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(b)

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