In Vivo Plasticity at Hippocampal Schaffer Collateral-CA1 Synapses: Replicability of the LTP Response and Pharmacology in the Long-Evans Rat

Figure 11

Memantine (3 and 10 mg/kg) had no significant effect on the -induced LTP response in LE rats. (a) Collective input/output curves between stimulation voltage and fEPSP slope overlap and show no significant difference in basal synaptic excitability. (b) A slight enhancement of LTP response was observed following both doses of memantine; however, the changes did not reach a significant level (green and blue, and , respectively) as compared to vehicle-treated animals (black, ). Values represent . Outsets above LTP curves represent average waveform field potentials during 30 min baseline prior to tetanisation and 0-30 min and 90-120 min posttetanisation. Horizontal bar: 1 mV; vertical bar: 5 ms. (c) PTP, STP, and LTP responses are presented as .

(a)

(b)

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