In Vivo Plasticity at Hippocampal Schaffer Collateral-CA1 Synapses: Replicability of the LTP Response and Pharmacology in the Long-Evans Rat

Figure 12

Acute treatment with MK-801 (5 mg/kg) significantly impaired the LTP response compared to controls. (a) Collective input/output curves between stimulation voltage and fEPSP slope overlap, showing no significant difference in basal synaptic excitability. (b) When compared to vehicle-treated subjects (black, ), acute treatment with MK-801 (red, ) significantly reduced the LTP response throughout the whole 2-hour posttetanisation. Values represent . Outsets above LTP curves represent average waveform field potentials during 30 min baseline prior to tetanisation and 0-30 min and 90-120 min posttetanisation. Horizontal bar: 1 mV; vertical bar: 5 ms. (c) PTP, STP, and LTP responses are presented as ; and .

(a)

(b)

(c)