In Vivo Plasticity at Hippocampal Schaffer Collateral-CA1 Synapses: Replicability of the LTP Response and Pharmacology in the Long-Evans Rat

Figure 14

PQ10 did not affect field postsynaptic potentials (fEPSP1 and fEPSP2) and paired-pulse facilitation (PPF) recorded at the SC-CA1 synapse during LTP. (a) Collective input/output curves between stimulation voltage and fEPSP slope overlap, showing no significant difference in basal synaptic excitability. (b) PQ10 () did not alter the induction and maintenance of LTP response measured from the slope of the fEPSP1 (blue) and fEPSP2 (red) as compared to vehicle-treated subjects (black and green, respectively, ). Values represent . Outsets above LTP curves represent average waveform field potentials during 30 min baseline prior to tetanisation and 0-30 min and 90-120 min posttetanisation. Horizontal bar: 1 mV; vertical bar: 5 ms. (c) PTP, STP, and LTP responses are presented as . ; ; and . (d) No difference in the paired-pulse facilitation of PQ10-treated and vehicle-treated subjects. The bar plot showing average PPR values during the 2-hour posttetanisation showed no significant difference between PQ10- and vehicle-treated subjects.

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