In Vivo Plasticity at Hippocampal Schaffer Collateral-CA1 Synapses: Replicability of the LTP Response and Pharmacology in the Long-Evans Rat

Figure 2

Differential synaptic LTP response to high-frequency stimulation in LE and SD rats. (a) Average input/output curves between stimulation voltage and fEPSP slope show no significant difference in basal synaptic excitability. (b) LTP responses to the 50/50 HFS protocol in LE rats (black, ) were significantly higher than in SD rats (green, ) through the whole 2-hour posttetanisation. Data are presented as . Outsets above the LTP curve represent average waveform field potentials during 30 min baseline prior to tetanisation and 0-30 min and 90-120 min posttetanisation. Horizontal bar: 1 mV; vertical bar: 5 ms. (c) PTP, STP, and LTP responses are presented as ; and ).

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