In Vivo Plasticity at Hippocampal Schaffer Collateral-CA1 Synapses: Replicability of the LTP Response and Pharmacology in the Long-Evans Rat

Figure 4

LTP response to different trains of the TBS protocol in Sprague-Dawley rats. As the number of TBS trains were increased, the LTP response increased in the SD rats. (a) Average input/output curves between stimulation voltage and fEPSP slope overlap for the study groups indicating no difference in basal synaptic excitability. (b) fEPSPs were enhanced compared to baseline following 2 trains of TBS (black, ), 5 trains of TBS (green, ), and 10 trains of TBS (blue, ); as the number of trains were increased, the larger was the fEPSP increase. LTP response induced by was significantly higher than both and throughout the whole 2-hour posttetanisation. Data are presented as . Outsets above LTP curves represent average waveform field potentials during 30 min baseline prior to tetanisation and 0-30 min and 90-120 min posttetanisation. Horizontal bar: 1 mV; vertical bar: 5 ms. (c) PTP, STP, and LTP responses are presented as . and .

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