In Vivo Plasticity at Hippocampal Schaffer Collateral-CA1 Synapses: Replicability of the LTP Response and Pharmacology in the Long-Evans Rat

Figure 5

LTP response to different trains of the TBS protocol in LE rats. (a) Collective input/output curves between stimulation intensities and fEPSP slope overlap, showing no significant difference in basal synaptic excitability. (b) When compared to 2 trains of TBS (black, ), there was a significant increase in the LTP response induced by 5 trains (green, ) and 10 trains (blue, ) of TBS. Values represent . Outsets above LTP curves represent average waveform field potentials during 30 min baseline prior to tetanisation and 0-30 min and 90-120 min posttetanisation. Horizontal bar: 1 mV; vertical bar: 5 ms. (c) PTP, STP, and LTP responses are presented as . ; ; and .

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