In Vivo Plasticity at Hippocampal Schaffer Collateral-CA1 Synapses: Replicability of the LTP Response and Pharmacology in the Long-Evans Rat

Figure 9

Donepezil (1 mg/kg) significantly enhanced LTP response when compared to control, saline-treated subjects. (a) Collective input/output curves of stimulation voltage and fEPSP slope overlap and show no significant difference in basal synaptic excitability prior to treatment with donepezil. However, the average response between 9 and 10 V showed a slightly lower response than control subjects in donepezil-treated subjects. (b) Basal fEPSPs were not affected; however, the LTP response of donepezil-treated subjects (green, ) was significantly greater than control, saline-treated subjects (black, ). Values represent . Outsets above LTP curves represent average waveform field potentials during 30 min baseline prior to tetanisation and 0-30 min and 90-120 min posttetanisation. Horizontal bar: 1 mV; vertical bar: 5 ms. (c) PTP, STP, and LTP responses are presented as ; and ).

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