Noncanonical Roles of hα-syn (A53T) in the Pathogenesis of Parkinson’s Disease: Synaptic Pathology and Neuronal Aging

Figure 1

Exogenous high hα-syn expression in the SNc. (a) Representative images showing mCherry-positive, TH-positive, and colabeled cells at 15 days after viral injection. (b) Ratios of colabeled cells in the total mCherry-positive cells in the SNc (). (c) Representative images showing mCherry-positive cells in the SNc at 15 days, 3 months, and 7 months after viral injection. (d) Number of mCherry-positive cells in the SNc at 15 days, 3 months, and 7 months after viral injection (). (e) Representative images showing hα-syn expression in the SNc by using immunohistochemistry at 3 months after viral injection. (f) Quantitative analysis of hα-syn expression in the SNc at 3 months after viral injection (). (g) Representative images showing hα-syn expression in SNc by using immunohistochemistry at 7 months after viral injection. (h) Quantitative analysis of hα-syn expression in the SNc at 7 months after viral injection (). compared with the control group.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)