Noncanonical Roles of hα-syn (A53T) in the Pathogenesis of Parkinson’s Disease: Synaptic Pathology and Neuronal Aging

Figure 2

Pathological characteristics of hα-syn in the SNc at 7 months after viral injection. (a) Representative images showing TH-positive cells in the SNc. (b) Number of TH-positive cells in the SNc (). (c) Representative images showing the inclusion of body-like structures in the SNc by using a transmission electron microscope (note: the red arrows indicate the inclusion of body-like structures in neurons). (d) p62 expression in ipsilateral midbrain tissues by using Western blot analysis. (e) Quantitative analysis of p62 expression in the ipsilateral midbrain by using image J software (). (f) Grp78 and CHOP expression levels in ipsilateral midbrain tissues by using Western blot analysis. (g, h)09 Quantitative analysis of Grp78 and CHOP expression levels in ipsilateral midbrain using image J software, respectively (). and compared with the control group.

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