Cyclin-Dependent Kinase-Like 5 (CDKL5): Possible Cellular Signalling Targets and Involvement in CDKL5 Deficiency Disorder

Figure 1

Primary structure and molecular phylogenetic tree of CDKL5. (a) Circular phylogenetic trees for the catalytic domains of CDKL5 and various kinases were generated using the CLC sequence viewer version 8.0. Scale bars indicate substitution rates of amino acids (50% amino acid substitution rate per bar length). (b) Schematic illustration of the primary structure of CDKL5 from human (accession no. NP_001310218.1), mouse (mCDKL5_1 in Hector et al. [29]), and zebrafish (accession no. NP_001124243.1) and of ERK2 from human (accession no. NP_620407.1). The catalytic domains of enzymes have been coloured blue and green, respectively. The TEY sequence corresponding to the activation loop is shown in yellow, the nuclear translocation sequence in purple, and the nuclear export sequence in orange. Amino acid identity between each catalytic region is shown.

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