Cyclin-Dependent Kinase-Like 5 (CDKL5): Possible Cellular Signalling Targets and Involvement in CDKL5 Deficiency Disorder

<div>Substitutions in the catalytic domain of CDKL5. CDKL5 has an N-terminal catalytic domain, with a conserved 12-subdomain structure of Ser/Thr kinases. Sites of missense and single amino acid deletion variants extracted from RettBASE (last accessed on September 9<sup>th</sup>, 2019), as well as Y177C, a variant discovered by the authors of the current review, are shown.</div>

Neural Plasticity

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Figure 4

Figure 4: Cyclin-Dependent Kinase-Like 5 (CDKL5): Possible Cellular Signalling Targets and Involvement in CDKL5 Deficiency Disorder 