Cyclin-Dependent Kinase-Like 5 (CDKL5): Possible Cellular Signalling Targets and Involvement in CDKL5 Deficiency Disorder

Table 1

Substrates of CDKL5.

Substrate	Localisation	Phosphorylation site(s)	Detection of phosphorylated protein	CDKL5 form	References
MeCP2	Nucleus	Not determined	In vitro	Full length and catalytic	[40, 42]
Dnmt1	Nucleus	Not determined	In vitro	Catalytic	[49]
NGL-1	Plasma membrane	RMNS^631KDN	In vitro	Full length	[38]
Amph1	Cytoplasm	Mus musculus: RPRS^293PSQ; Danio rerio: RPTS^285PGP and RPKS^293PSQ	In vitro	Full length and catalytic	[32, 44, 78]
HDAC4	Cytoplasm and nucleus	RAQS^632SPA	In vitro	Full length	[39]
MAP1S	Cytoplasm	Mus musculus: RPSS^786ASA and RPLS^812ARS; Homo sapiens: RPLS^900ARS	In vitro and in vivo	Full length	[70, 71]
CEP131	Cytoplasm (centrosome)	RPGS^35AAT	In vitro	Full length	[70]
DLG5	Cytoplasm	RPKS^1115APS	In vitro	Full length	[70]
ARHGEF2	Cytoplasm	RPTS^122AIY	In vitro	Full length	[71]
EB2	Cytoplasm	RPSS^222AKR	In vitro and in vivo	Full length	[71]
SMAD3	Cytoplasm and nucleus	Not determined	In vitro	Full length	[77]