Neuroprotective Effects of the Sonic Hedgehog Signaling Pathway in Ischemic Injury through Promotion of Synaptic and Neuronal Health

Figure 1

Effects of OGD exposure on the Shh signaling pathway: (a) protein levels of Shh, Gli-1, and patch at 1, 2, 4, 8, and 24 h after OGD exposure as determined by Western blot (/group); (b) nuclear translocation of Gli-1 at 24 h after OGD was observed with the use of immunofluorescent staining ( μm). Quantification of Gli-1 nuclear translocation (/group). Values represent the ; , , and according to ANOVA according to ANOVA with Dunnett test in (a) and Tukey’s post hoc comparisons in (b).

(a)

(b)