Analysis of Crucial Genes and Pathways Associated with Spared Nerve Injury-Induced Neuropathic Pain

Figure 3

Protein-protein interaction (PPI) network constructed by cluster genes in three clusters, five modules, and KEGG pathway analysis for module genes. (a) The PPI network and (b) five modules. Red nodes represent cluster 1 genes, blue nodes represent cluster 2 genes, and green nodes represent cluster 3 genes. Circle nodes represent upregulated genes, and rhombus nodes represent downregulated genes. Node size represents the degree of connectivity. (c) KEGG pathway analysis for module genes. Bubble size indicates the number of enriched genes. The redder the bubble color, the more significant this pathway.

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