Mesenchymal Stromal Cells Suppress Hippocampal Neuron Autophagy Stress Induced by Hypoxic-Ischemic Brain Damage: The Possible Role of Endogenous IL-6 Secretion

<div>Separate siIL-6 MSC coculture increased Beclin 1 and LC3 II protein expression levels and reduced IL-6 and p62 protein expression levels, as well as increased the number of autophagosomes in hippocampal neurons injured by OGD, following damage for 12 h and 24 h. (a) Representative western blots of IL-6, Beclin 1, LC3 II, and p62 protein expression levels in the OGD-injured neurons cocultured with siIL-6 MSCs or GFP MSCs for 12 h and 24 h. (b–e) Quantification analysis of the neuron protein expression levels normalized to <i>β</i>-actin for the two groups. 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Neural Plasticity

fig4

Figure 4

Figure 4: Mesenchymal Stromal Cells Suppress Hippocampal Neuron Autophagy Stress Induced by Hypoxic-Ischemic Brain Damage: The Possible Role of Endogenous IL-6 Secretion 

Figure 4 | Mesenchymal Stromal Cells Suppress Hippocampal Neuron Autophagy Stress Induced by Hypoxic-Ischemic Brain Damage: The Possible Role of Endogenous IL-6 Secretion 