Mesenchymal Stromal Cells Suppress Hippocampal Neuron Autophagy Stress Induced by Hypoxic-Ischemic Brain Damage: The Possible Role of Endogenous IL-6 Secretion

Figure 6

siIL-6 MSC transplantation increased hippocampal neuron p-AMPK protein expression levels and decreased p-mTOR levels following damage for 12 h and 24 h. (a) Representative western blots of hippocampal p-AMPK, AMPK, p-mTOR, and mTOR protein expression levels in the HIBD+siIL-6 MSC and HIBD+GFP MSC groups. (b, c) The ratio of p-AMPK/AMPK and p-mTOR/mTOR protein expression levels in the hippocampus (, ). (d) Representative western blots of the p-AMPK, AMPK, p-mTOR, and mTOR protein expression levels in the OGD+siIL-6 MSC and OGD+GFP MSCs group. (e, f) The ratio of p-AMPK/AMPK and p-mTOR/mTOR protein expression levels in the two groups (, ).

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