Inhibited CSF1R Alleviates Ischemia Injury via Inhibition of Microglia M1 Polarization and NLRP3 Pathway

Figure 5

Ki20227 administration inhibited NLRP3 pathway activation. Western blot of (a) NLRP3, NF-κB, cleaved caspase 1, pro-caspase 1, and GADPH for normal, sham, stroke, stroke+PBS, and stroke+Ki20227 groups. Statistical analyses of (b) NLRP3, (c) NF-κB, and (d) cleaved caspase 1/pro-caspase 1. Normal group vs. stroke group, ; normal group vs. stroke+PBS group, ; stroke+Ki20227 group vs. stroke group, ^##, ^###; stroke+PBS vs. stroke+Ki20227 groups, ^^, ^^^.

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