Research Article

Cochlear Implantation in a Patient with a Novel POU3F4 Mutation and Incomplete Partition Type-III Malformation

Figure 4

Structural simulation of Pou3f4. Compared with the wild-type (WT) protein, the structure of the mutant protein is incomplete, leading to lose the DNA-binding ability. The POUs (yellow) and POUHD (blue) domains are shown in different colors.