An Enriched Environment Enhances Angiogenesis Surrounding the Cingulum in Ischaemic Stroke Rats

Figure 4

The enriched environment increased VEGF expression surrounding the contralateral cingulate. At 14 days after MCAO/r, VEGF surrounding the bilateral cingulate were measured and analysed by immunostaining. (a–d) Representative images of VEGF-positive cells surrounding the contralateral cingulate in MCAO/r rats in the standard cage ((a) ; (c) ) and enriched environment groups ((b) ; (d) ). (e) The number of VEGF cells surrounding the contralateral cingulate in MCAO/r rats in the SC and EE groups was quantified and analysed. rats per group,. (f–i) VEGF-positive cells surrounding the ipsilateral cingulate in MCAO/r rats in the standard cage ((f) ; (h) ) and enriched environment ((g) ; (i) ) groups were measured and quantified (j). rats per group.