Xiaoyao Pills Attenuate Inflammation and Nerve Injury Induced by Lipopolysaccharide in Hippocampal Neurons In Vitro

Figure 4

Xiaoyao Pills prevent LPS-induced reduction of neurotrophic factor. Representative blots of relative protein expression of TrkB, CREB, and p-CREB (a). Xiaoyao Pill serum (4% and 8%) improved the levels of BDNF (b) and β-NGF (c) in supernatant and increased the transcription level of BDNF (d), NGF (e), TrkB (f), TrkA (g), and CREB (i) and the translation levels of TrkB (h), CREB (k), and p-CREB (j) in cell lysate, as well as the ratio of p-CREB/CREB (l) higher than the LPS group. The results were expressed as the (). ^&& compared to the control group. and compared to the LPS group. ^## and ^## compared to the LPS+4% control serum group. ^$ and ^$$ compared to the LPS+8% control serum group.

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