Study Species/tissue miRNA Result/target genes Wang et al. [27 ] Stroke patient miR-124 BDNF Zeng et al. [28 ] Striatum miR-210 BDNF Liu et al. [29 ] Stroke patient miR-922 The SNP rs7124442 in BDNF 3 Lu et al. [31 ] Hippocampus miR-10b-5p BDNF Varendi et al. [32 ] Cellular model miR-155 BDNF Summary of related acupuncture literatures Study Species/tissue Method/acupoint Stimulation parameter Result Tao et al. [34 ] Cortex and striatum EA at LI11, ST36 1 Hz/20 Hz, 30 min BDNF ↑ Kim et al. [35 ] Striatum and hippocampus EA at GV20, GV14 2 Hz, 1 mA, 20 min BDNF ↑ Jiang [36 ] Whole brain EA at GV20, GV16 2 Hz/30 Hz, 30 min, 2 V BDNF ↑ Kim et al. [37 ] Whole brain EA at GV20, GB7 3 Hz, 5 min BDNF ↑ Zhou [38 ] Cortex EA at PC6, ST36 2 Hz/30 Hz, 30 min, 5 mA BDNF ↑ Teng. [39 ] Whole brain MA at GV20-GB7 scalp cave Needles were turned at a rate of three revolutions per second, twirled 3 times for 5 min, and retained for 30 min BDNF ↑ Zhang et al. [40 ] Hippocampus MA at nape cluster acupoints 15 min/day BDNF ↑ Ye et al. [41 ] Cortex EA at LI11, ST36 1 Hz/20 Hz, 30 min, 6 V BDNF ↑ Liu [42 ] Hippocampus EA at GV20, GV24 2 Hz/20 Hz, 30 min, 6 V miR-219a ↓ Zhou et al. [21 ] Neurons and cortexes EA at GV20 1 mA, 30 min miR-191a-5p ↓ Zhao et al. [43 ] Ischaemic penumbra EA at GV20 2 Hz/10 Hz, 1-2 mA, 30 min miR-132 ↑ Liu et al. [26 ] Peri-infarct cortex EA at GV20, GV24 1 Hz/20 Hz, 0.2 mA, 6 V, 30 min miR-134 ↓ Liu et al. [44 ] Peri-infarct cortex EA at LI11, ST36 1 Hz/20 Hz, 4 V, 30 min miR-9 ↑ Zheng et al. [45 ] Cortex EA at GV26, PC6 2 Hz, 3 mA, 1 min miR-494 ↓, miR-206 ↑ Deng et al. [46 ] Ischaemic penumbra EA at GV20 2 Hz/10 Hz, 1-2 mA, 30 min miR-181b ↑
