Applications of Acupuncture Therapy in Modulating the Plasticity of Neurodegenerative Disease and Depression: Do MicroRNA and Neurotrophin BDNF Shed Light on the Underlying Mechanism?

Table 3

Deregulated miRNAs and target genes of Alzheimer’s disease and summary of related electroacupuncture literatures.

Study	Species/tissue	miRNA	Result/target genes
Vo et al. [93]	Cortical neurons	miR-132	BDNF triggered the rapid induction and persistent expression of mature miR-132
Numakawa et al. [94]	Cortical neurons	miR-132	BDNF increased levels of synaptic proteins via upregulation of miR-132
Tian et al. [96]	Hippocampus	miR-206	BDNF
Mellios et al. [61]	Prefrontal cortex	miR-30a-5p; miR-195	Both miR-30a-5p and miR-195 targeted BDNF
Li et al. [97]	AD patients and mouse model	miR-613	BDNF
Wu et al. [98]	Neuronal cells	miR-10a	BDNF
Zhang et al. [16]	Mouse brain	miR-322	BDNF
Summary of related electroacupuncture literatures
Study	Species/tissue	Method/acupoint	Stimulation parameter	Result
Wang et al. [100]	Hippocampus	EA at BL23, GV14, PC6	2 Hz, 1 mA, 20 min	BDNF ↑
Zhang et al. [101]	Hippocampus and cortex	EA at GV20, GV16	150 Hz, 15 min	BDNF ↑
Li et al. [102]	Hippocampus and cortex	EA at GV20	2 Hz/15 Hz, 1 mA, 30 min	BDNF ↑
Lin et al. [103]	Hippocampus	EA at GV20	1 Hz/20 Hz, 30 min	BDNF ↑

EA: electroacupuncture.