Neural Plasticity / 2020 / Article / Tab 4 / Review Article
Applications of Acupuncture Therapy in Modulating the Plasticity of Neurodegenerative Disease and Depression: Do MicroRNA and Neurotrophin BDNF Shed Light on the Underlying Mechanism? Table 4 Deregulated miRNAs and target genes of depression and summary of related acupuncture literatures.
Study Species/tissue miRNA Result/target genes Yang et al. [119 ] Hippocampus miR-206 BDNF Wang et al. [120 ] Hippocampus miR-124 miR-124 produced antidepressant-like effects by activating the BDNF-TrkB signalling pathway Sun et al. [122 ] Cellular model miR-16 BDNF Varendi et al. [32 ] Cellular model miR-155 BDNF Summary of related acupuncture literatures Study Species/tissue Method/acupoint Stimulation parameter Result Zhang et al. [126 ] Hippocampus MA at GV20, GV29 Needles were twirled for 1 min and retained for 10 min BDNF ↑ Luo et al. [127 ] Hippocampus EA at GV20, GV29 2 Hz, 2 mA, 20 min BDNF mRNA ↑, BDNF ↑ Duan et al. [128 ] Hippocampus EA at GV20, GV29 2 Hz, 0.6 mA, 30 min BDNF ↑ Jiang et al. [129 ] Hippocampus MA at GV20, GV29 20 min/day BDNF ↑ Yang et al. [130 ] Hippocampus EA at GV20 and GV29 combined with citalopram 2 Hz/100 Hz BDNF ↑ Park et al. [131 ] Prefrontal cortex MA at HT7 Needles were turned at two revolutions per second for 15 s and removed immediately afterward BDNF ↑ Zhao et al. [132 ] Hippocampus EA at GV20 and GV29 2 Hz, 1 mA, 20 min miR-16 ↓
MA: manual acupuncture; EA: electroacupuncture.
