Cisplatin-Induced Stria Vascularis Damage Is Associated with Inflammation and Fibrosis

Figure 1

Cisplatin induced insult to auditory function. (a) C57BL/6 mice were divided into 2 groups and given i.p. injection of drugs as illustrated. (b) Endocochlear potentials were measured 7 days after cisplatin administration (3 mg/day/kg, i.p.). The EP in cisplatin-treated mice was significantly reduced compared to the control group (). (c) ABR thresholds were measured at 4, 8, 12, 16, 24, and 48 kHz in the control and cisplatin groups, and the ABR thresholds were elevated in the cisplatin group compared to the control group at all frequencies measured (). Data are shown as . Cis: cisplatin; .

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