Distinct Associations of Cognitive Impairments and Reduced Gray Matter Volumes in Remitted Patients with Schizophrenia and Bipolar Disorder

Table 2

Clusters showing significant differences across BD, SZ, and HC groups with one-way ANCOVA.

Cluster	Brain regions	Voxels	Peak MNI coordinate					Post hoc analysis
			A	R-dorsolateral superior frontal gyrus	1638				24	49.5	28.5	11.629	<0.001	SZ<HC (); BD < HC (P = 0.022); SZ vs BD (p = 0.336)
B	L-orbital middle frontal gyrus; L-middle frontal gyrus; L-orbital superior frontal gyrus	1444	-28.5	60	-2.84	12.008	<0.001	SZ<HC (); BD<HC (); SZ vs. BD ()
C	L-rectus; R-rectus	1420	-7.5	36	-21	11.090	<0.001	SZ<HC (); BD<HC (); SZ vs. BD ()
D	R-insula; R-temporal pole-superior temporal gyrus; R-amygdala	1319	34.5	7.5	-19.5	13.476	<0.001	SZ<HC (); BD<HC (); SZ vs. BD ()
E	L-superior temporal gyrus	943	-61.5	-58.5	15	15.155	<0.001	SZ<HC (); BD vs. HC (); SZ<BD ()
F	L-insula	906	-33	7.5	19.5	12.144	<0.001	SZ<HC (); BD<HC (); SZ vs. BD ()
G	L-dorsolateral superior frontal gyrus; L-middle frontal gyrus; L-anterior cingulate and paracingulate gyri	856	-19.5	58.5	25.5	15.475	<0.001	SZ<HC (); BD<HC (); SZ vs. BD ()
H	L-insula; L-opercular inferior frontal gyrus; L-temporal pole-superior temporal gyrus	811	-48	16.5	1.5	14.456	<0.001	SZ < HC (P < 0.001); BD < HC (P = 0.004); SZ vs BD (p = 0.421)
I	R-medial superior frontal gyrus	797	3	60	-1.5	10.622	<0.001	SZ<HC (); BD<HC (); SZ vs. BD ()
J	R-supramarginal gyrus	565	64.5	-16.5	28.5	11.030	<0.001	SZ<HC (); BD vs. HC (); SZ<BD ()

GRF, Gaussian random field corrections; MNI, Montreal Neurological Institute; L, left; R, right; , coordinates of peak voxel. Significant at . Post hoc analysis is the Bonferroni correction.