Research Article
Bushen-Tiansui Formula Improves Cognitive Functions in an Aβ1–42 Fibril-Infused Rat Model of Alzheimer’s Disease
Figure 3
Oral administration of BTF prevents synaptic loss in Aβ1–42 fibril-infused rats. (a) Representative electron micrographs of synapses. Red arrows indicate the synapses. Scale bar, 1 μm. (b–g) Quantitative analysis of the synaptic density (b) (, ) and the parameters of synaptic structure in the AC1 region. Data are presented as for the percentage of perforated synapses (c) (, ), synaptic active zone length (d) (, ), synaptic cleft width (e) (, ), PSD thickness (f) (, ), and synaptic interface curvature (g). in each group. (h) Immunoblotting analysis of synaptic markers in brain homogenates from rats treated with saline or BTF. BTF treatment increased the expression of synaptic markers in Aβ1–42 fibril-infused rats. , and # by one-way ANOVA with Tukey’s multicomparison test compared with saline-treated Aβ1–42 fibril-infused rats. Western blot data are representative of three independent experiments.
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