Predisposition of Neonatal Maternal Separation to Visceral Hypersensitivity via Downregulation of Small-Conductance Calcium-Activated Potassium Channel Subtype 2 (SK2) in Mice

Figure 5

Effects of SK2 channel blocker apamin on anxiety- and depression-like behaviors. (a) Representative activity traces of control mice and mice with apamin injection in the elevated plus maze. (b–d) There was an insignificant difference in the duration spent in the open arms (-test, , ), the times of entry into the open arms (-test, , ), and the total distances travelled (-test, , ) between the two groups ( per group). (e) Schema of the open field and the representative activity traces during an open field test in control mice and mice with apamin injection. (f–h) There was an insignificant difference in the duration in the arena (-test, , ), the courses in the arena (-test, , ), and the total distances travelled (-test, , ) between the two groups ( per group). (i) Schema of the sucrose preference test. (j) The percentage of the sucrose intake volume over the total fluid intake volume in mice with apamin injection was consistent with that in control mice (-test, , , per group). (k) Schematic representation of mobility and immobility in the forced swim test. (l) The percentage of immobility duration over the total time in mice with apamin injection was consistent with that in control mice (-test, , , per group). Data are expressed as .

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