Predisposition of Neonatal Maternal Separation to Visceral Hypersensitivity via Downregulation of Small-Conductance Calcium-Activated Potassium Channel Subtype 2 (SK2) in Mice

Figure 7

Effects of SK2 activator 1-EBIO on anxiety- and depression-like behaviors. (a) Representative activity traces of control mice and mice with 1-EBIO injection in the elevated plus maze. (b–d) There was an insignificant difference in the duration spent in the open arms (-test, , ), the times of entry into the open arms (-test, , ), and the total distances travelled (-test, , ) between the two groups ( per group). (e) Schema of the open field and the representative activity traces during an open field test in control mice and mice with 1-EBIO injection. (f–h) There was an insignificant difference in the duration in central area (-test, , ), the courses in the central area (-test, , ), and the total distances travelled (-test, , ) between the two groups ( per group). (i) Schematic diagram of the sucrose preference test. (j) The percentage of the sucrose intake volume over the total fluid intake volume in mice with 1-EBIO injection was consistent with that in control mice (-test, , , per group). (k) Schematic representation of mobility and immobility in the forced swim test. (l) The percentage of immobility duration over the total time in mice with 1-EBIO injection was consistent with that in the control mice (-test, , , per group). Data are expressed as .

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