Research Article
Aβ-Induced Repressor Element 1-Silencing Transcription Factor (REST) Gene Delivery Suppresses Activation of Microglia-Like BV-2 Cells
Figure 4
REST repressed proinflammation cytokine TNF-α, IL-1β, and IL-6 expression and secretion. (a) Aβ1-42 induced proinflammation cytokine TNF-α, IL-1β, and IL-6 upregulation and anti-inflammation cytokine IL-12 downregulation. (b) Knockdown REST gene induced proinflammation cytokine TNF-α, IL-1β, and IL-6 mRNA upregulation with the treatment of Aβ1-42. (c) Knockdown REST gene increased secretion of proinflammation cytokines TNF-α, IL-1β, and IL-6. vs. control, vs. control, and vs. control.
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