Aberrant Advanced Cognitive and Attention-Related Brain Networks in Parkinson’s Disease with Freezing of Gait

Table 2

Brain regions in resting-state networks (RSNs) with significant differences in functional connectivity among FOG+, FOG-, and HC participants.

RSNs/regions (AAL)	Cluster size (mm^3)	Peak MNI coordinates ()			Peak -value
		AUN
TPS.L	104	-45	3	-15	24.1194
PreCG.R	45	54	3	27	30.5567
MCG.R	96	6	30	33	29.8302
DMN
SFGmed.L	21	-3	66	6	30.5884
PCUN.L	1297	6	-63	36	97.2039
ANG.L	95	-48	-57	27	42.8589
ANG.R	109	51	-54	36	28.296
DAN
ITG.R	56	51	-60	-9	23.913
PCUN.R	64	15	-57	15	45.5962
IFGoperc.R	182	57	9	27	62.9567
SMG.R	1117	42	-27	42	69.4657
PCUN.L	2853	3	-63	54	175.8931
LFPN
ITG.L	20	-66	-48	-12	84.2057
ORBmid.L	20	-33	57	-12	41.5616
RFPN
MFG.R	27	33	21	51	21.3332
SMN
SMA.L	152	3	3	72	24.0919
VIN
MOG.R	631	39	-90	3	65.4637
MOG.L	817	-27	-99	9	66.4165

The -value was obtained by post hoc analysis of one-sample -tests, corrected , cluster extent threshold of 20 voxels. FOG+/FOG-: Parkinson’s disease with/without freezing of gait; HC: healthy controls; MNI: Montreal Neurological Institute; L/R: left/right hemisphere; AUN: auditory network; TPS: temporal pole: superior temporal gyrus; PreCG: precentral gyrus; MCG: median cingulate and paracingulate gyrus; DMN: default mode network; SFGmed: superior frontal gyrus, medial; PCUN: precuneus; ANG: angular gyrus; DAN: dorsal attention network; ITG: inferior temporal gyrus; IFGoperc: inferior frontal gyrus, opercular part; SMG: supramarginal gyrus; LFPN: left frontoparietal network; ORBmid: middle frontal gyrus, orbital part; RFPN: right frontoparietal network; MFG: middle frontal gyrus; SMN: somatomotor network; SMA: supplementary motor area; VIN: visual network; MOG: middle occipital gyrus.