Stress-Sensitive Protein Rac1 and Its Involvement in Neurodevelopmental Disorders

Table 1

List of small-molecule compounds that inhibit Rac1 activity.

Compound name	Formula	Molecular weight	Target Rac1 signaling	Target other Rho GTPases	Reference
NSC23766	C24H35N73HCl	530.96	Inhibit TIAM1 and TRIO	None	[114]
ITX3	C22H17N3OS	371.45	TRIO	RhoG and Rac1	[122]
EHop-016	C25H30N60	430.55	Inhibit Vav2	Rac3, Cdc42	[120]
AZA1	C22H20N6	368.43	Rac1/PAK1	Cdc42	[119]
1A-116	C16H16F3N3	307.31	Rac1/P-Rex-1	None	[123, 127]
ETH 1864	C25H27F3N204S2HCI	581.47	Rac1/TIAM1	Rac1b, Rac2, Rac3	[128]
FRAX486	C25H23Cl2FN6O	513.39	PAK1-3	None	[71, 83]