Exercise-Induced Cognitive Improvement Is Associated with Sodium Channel-Mediated Excitability in APP/PS1 Mice

Figure 4

Late 12-week treadmill exercise improved spatial learning and memory in APP/PS1 mice. In the hidden platform test, the escape latencies of WT or APP/PS1 mice over 5 d were recorded (a). In the probe test, the percentage of time spent in the target quadrant (b), typical probe traces (c), percentage of path traveled in the target quadrant (d), and number of target crossings (e) for 6.5 m, 8 m, and 9.5 m WT and APP/PS1 mice with or without exercise and WT mice were compared. WT: wild type; SC: sedentary control; TE: treadmill exercise. WT vs. TE, ; WT vs. SC, ; TE vs. SC, .

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