Early Repetitive Transcranial Magnetic Stimulation Exerts Neuroprotective Effects and Improves Motor Functions in Hemiparkinsonian Rats

Figure 2

Design of the study of the long-term treatment effects of rTMS on rats with 6-OHDA-induced PD. rTMS and sham control treatments were performed daily over 4 successive weeks. Behavioral tests, including gait analysis, the bar test, and apomorphine-induced rotation tests, were performed every week to investigate the time-course treatment effects. Immunohistochemistry tests were performed at week 1 and week 4 post-6-OHDA lesion to identify the neuroprotective effects rTMS treatment on dopaminergic neurons and fibers.