Levodopa Challenge Test Predicts STN-DBS Outcomes in Various Parkinson’s Disease Motor Subtypes: A More Accurate Judgment

Table 1

Comparison of baseline and postoperative indices among the three subtype groups in the training set.

	Total ()	TD ()	AR ()	MX ()	ANOVA	TD vs. AR	TD vs. MX	AR vs. MX
Sex (male/female)	87/60	10/14	29/17	48/29
Reach MICID in UPDRS-III ()	58 (39.5%)	11 (45.8%)	18 (39.1%)	29 (37.7%)
Reach MOCID in PDQ-39 ()	76 (51.7%)	10 (41.7%)	26 (56.5%)	40 (51.9%)
Age at surgery (years)					0.053
Age at onset (years)					0.009	0.008	0.295	0.131
DD (years)					0.106
Duration of MF (years)					<0.001	<0.001	0.088	0.030
H-Y on					0.007	0.005	0.128	0.239
H-Y off					0.049	0.043	0.219	0.843
UPDRS-III on					0.102
UPDRS-III off					0.030	0.381	1.000	0.126
LR for UPDRS-III (%)					0.230
LR for tremor score (%)					0.107
LR for akinetic-rigid score (%)					<0.001	<0.001	<0.001	1.000
LEDD					0.021	0.068	1.000	0.040
PDQ-39					<0.001	<0.001	0.014	0.135
HAMD					0.150
HAMA			13.4 ± 2.9	12.5 ± 2.6	0.025	0.027	0.527	0.187
Post UPDRS-III on					0.002	0.007	1.000	0.006
Post UPDRS-III off					0.002	0.005	0.813	0.012
Post PDQ-39					<0.001	<0.001	0.006	0.120

TD: tremor-dominated patients; AR: akinetic-rigid-dominated patients; MX: mixed patients; MICID: minimal clinically important difference; MOCID: moderate clinically important difference; DD: duration of diagnosis; MF: motor fluctuation; H-Y: Hoehn-Yahr stage; UPDRS: Unified Parkinson’s Disease Rating Scale; LR: levodopa response; LEDD: levodopa equivalent doses; PDQ-39: Parkinson’s Disease Questionnaire-39; HAMD: Hamilton depression scale; HAMA: Hamilton anxiety scale; Post: postoperative; Post UPDRS-III on: on-stimulation/on-medicine; Post UPDRS-III off: on-stimulation/off-medicine. value. Significant comparisons are highlighted in bold.